After that, the new INTERSALT study, hence documented an optimistic connection within urinary Na + /K + proportion and you may blood pressure levels reported a loss in statistical requirement for the relationship from inside the 44 of your own 52 locations after modifications getting covariates in addition to decades, gender and you will Bmi [thirty two, 33]

At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The TAIM randomized control trial in hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . Despite several prior studies reporting an association between blood pressure and the urinary Na + /K + ratio there are several limitations to be considered. conducted in hypertensive participants reported a significant reduction in SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].

The modern research has numerous benefits: (1) Brand new Dashboard -Salt trial are a very carefully regulated feeding research and you can conformity is actually constantly tracked, (2) The newest crossover design for Na + input desired participant’s to act as their own handle and you may reduced inter-individual variability, (3) 24-h ambulatory hypertension recordings was drawn, (4) absence of the fresh confounding aftereffects of antihypertensive mediations, and you may (5) 24-h pee try range. The major limit of your own establish studies ‘s the seemingly small try size that can provides diminished our very own mathematical capability to choose small outcomes of urinary Na + , K + , and you may Na + :K + proportion on the SBP. As we failed to observe an instability for the standard functions, residual confounding inside our research is possible.

A good multicenter study from the Suppa ainsi que al

In conclusion the modern analysis of Dashboard–Salt Demo implies that weight loss K + supplements is not for the all the way down SBP which the newest decreases for the SBP observed pursuing the Dash fat loss input taken place separately away from a great reduced total of the fresh new urinary Na + /K + removal proportion irrespective of the latest sodium sensitiveness out of blood pressure. Our very own studies do not keep the facilities away from a-1:step 1 molar removal proportion from Na + /K + as the blood bbwdesire pressure levels minimizing strategy inside All of us African american and you may low-African People in america and you can support the DRI recommendation never to recommend daily K + intake recommendations. Given the limitations of the latest research together with constant controversy concerning your part regarding slimming down K + with the blood pressure level coming very carefully managed studies are needed to elucidate the potential perception from diet K + and you can urinary Na + /K + removal proportion on the blood circulation pressure in both hypertensive and you can normotensive SS and you can SR members.